So, which would be considered an optimal user experience in the current digital era?
First, we would have to consider the platform that we will be designing for.
For mobile phones and tablets, it has lengthier vertical dimensions, which makes it ideal for vertical scroll designs (feasible for horizontal scroll designs if the application runs in horizontal mode, such as games, video streaming etc.). However, we do see a trend in a mixture of both horizontal and vertical scroll design incorporated within applications, such as the Netflix app, which consists of sub categories which group the individual shows (design term "cards"), highlighted in blue below. This is called the contained collection, in which it allows users to be made known of that it is horizontally scrollable, by having a portion of the card, highlighted in green below, hidden out of width.

Netflix Mobile App
For bigger screen interfaces such as tablets and laptops, it has lengthier horizontal dimensions, which makes it ideal for horizontal scroll designs, however, there would still be a set guideline on the maximum amount of items placed horizontally for scroll, as it would not be a good user experience for the user to be scrolling endlessly for a minute or more to their desired item of interest.
Thus, for all platforms, be it big or small, will have to adhere to a visual hierarchy for a better user experience.

Thumb zone mapping for Left, Right handed
Image SourceBased on the diagram, it shows the optimal mappings for thumb interactions on a mobile phone.
It is divided into 3 circumstances:
- Natural (Easiest to achieve)
- Stretching (Moderate to achieve)
- Hard (Hardest to achieve)
Thumb interactions, comfort level should be a design consideration that designers must think of when understanding how to optimally improve or create a good user experience. Users should be able to access to functions / buttons with ease, and with minimal instructions or explanation needed.

Swipe gestures data collected from user testing
Image SourceIt is also easier to achieve smoother thumb movement vertically due to the way how mobile phones are made, and how we hold our mobile phones vertically.
With relevancy and retained knowledge from existing designs of other applications, it will be generally assumed by users that the reading and viewing structure of content would be vertical. Non-drastic, minimal changes to such reading, viewing norms can be challenged, but it should not affect the user’s basic experience of going through content, albeit there would be drop-off rates in the initial phase for users who don’t feel natural, comfortable in using the application.